You Will NEVER EAT Sugar Again After WATCHING THIS! | Dr. David Perlmutter

Last updated: Jun 1, 2023

The video is about Dr. David Perlmutter discussing the importance of personalized medicine and tracking data points such as genome and microbiome to improve overall health and reverse damage caused by lifestyle choices.

The video features an interview with Dr. David Perlmutter, a board-certified neurologist and bestselling author, discussing how to reverse the damage caused by lifestyle choices to the gut, the four metrics of health, the real cause of Alzheimer's, and the secret to effective aerobic exercise. Dr. Perlmutter also talks about the importance of personalized medicine and biometrics, and recommends understanding one's genome as a starting point for tracking and manipulating data to understand one's current needs. He also shares his personal experience of learning about his poor methylator genes and how it changed his lifestyle choices.

  • Dr. David Perlmutter believes in challenging traditional medicine and predicts an explosion in personalized medicine using big data and artificial intelligence.
  • Personalized medicine involves tracking individual data points such as genome and microbiome to improve overall health.
  • Tracking data points such as heart rate variability, sleep quality, and glucose levels can provide valuable insights into our health.
  • Eating a diet low in sugar and carbohydrates and high in healthy fats can help improve gut health.
  • Low insulin levels may increase the risk of dementia in women.
  • Cholinesterase inhibitors have not shown any efficacy in treating Alzheimer's.
  • Exercise is a powerful way to reduce the risk of dementia.
  • Alzheimer's drugs that target beta amyloid have not been effective.
  • Plaque is the response to the problem, not the cause of the problem.

You Will NEVER EAT Sugar Again After WATCHING THIS! | Dr. David Perlmutter - YouTube

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Introduction

  • Dr. David Perlmutter is a board-certified neurologist and a bestselling author.
  • He believes in challenging the status quo and disrupting traditional medicine.
  • He predicts an explosion in the ability to harness big data and use artificial intelligence to make personalized recommendations for individuals.
  • He believes that personalized medicine and biometrics will become more accessible to the larger audience.
  • He thinks that we will learn what really has traction with respect to the broad strokes of personalized medicine.
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Personalized Medicine

  • Personalized medicine involves using big data and artificial intelligence to make specific recommendations for individuals based on their genome, microbiome, and lifestyle choices.
  • It is important to understand our genomes and manipulate the data to understand our current needs.
  • Several online sites are available to upload your 23andme data to learn more about your genome.
  • Dr. Ben Lynch's site is a great resource to learn not just what your genome says, but what it means.
  • Personalized medicine and biometrics will become more accessible to the larger audience.
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Tracking Data Points

  • It is important to track changes in your microbiome on almost a daily basis.
  • Understanding your genome is a great place to start, but our day-to-day lifestyle choices are hugely influential on the expression of our life code.
  • Tracking data points such as heart rate variability, sleep quality, and glucose levels can provide valuable insights into our health.
  • Wearing an aura ring or a constant glucose monitor can be helpful in tracking these data points.
  • Tracking data points can help us make more informed decisions about our health and lifestyle choices.
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You Will NEVER EAT Sugar Again After WATCHING THIS! | Dr. David Perlmutter - YouTube

Reversing Damage to the Gut

  • Our lifestyle choices can cause damage to our gut, but it is possible to reverse this damage.
  • Eating a diet low in sugar and carbohydrates and high in healthy fats can help improve gut health.
  • Probiotics and prebiotics can also be helpful in improving gut health.
  • Intermittent fasting can help improve gut health by giving the gut a break from digestion.
  • Reducing stress and getting enough sleep are also important for gut health.
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Importance of Tracking Data Points

  • Homocysteine level is a risk factor for Alzheimer's and can be modifiable through lifestyle factors.
  • Other important data points to track include vitamin D level, fasting glucose level, ketone levels, and hemoglobin A1C.
  • Low insulin levels may increase the risk of dementia in women.
  • Polymorphisms of genes and a low sugar, low carbohydrate diet can help lower insulin levels.
  • There is currently no treatment for Alzheimer's, and Alzheimer's drugs do not work and may even speed cognitive decline.
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Risks of Low Insulin Levels

  • Low insulin levels may increase the risk of dementia in women by 2.38 times.
  • At the high range, the risk is increased by 1.7 times.
  • Lower insulin levels are not necessarily better for overall health.
  • Gene expression and a low sugar, low carbohydrate diet can help lower insulin levels.
  • Alzheimer's drugs do not work and may even speed cognitive decline.
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Cholinesterase Inhibitors

  • Cholinesterase inhibitors are drugs that inhibit an enzyme that degrades a neurotransmitter called acetylcholine.
  • These drugs are used to treat Alzheimer's by increasing acetylcholine levels in the brain.
  • Cholinesterase inhibitors have not shown any efficacy in treating Alzheimer's.
  • Alzheimer's drugs do not work and may even speed cognitive decline.
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Importance of Personalized Medicine

  • Personalized medicine involves tracking individual data points such as genome and microbiome to improve overall health.
  • Modifiable lifestyle factors can help reduce the risk of Alzheimer's and other diseases.
  • There is currently no treatment for Alzheimer's, and Alzheimer's drugs do not work and may even speed cognitive decline.
  • Tracking data points can help individuals make informed decisions about their health and reduce their risk of disease.
  • Personalized medicine is the future of healthcare.
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The Importance of Beta Amyloid

  • Plaque is the response to the problem, not the cause of the problem.
  • Beta amyloid is an antimicrobial peptide that responds to infectious agents.
  • Getting rid of beta amyloid has been tried in clinical trials, but patients declined much more quickly.
  • Pfizer has stopped pursuing the notion of an Alzheimer's drug that targets beta amyloid.
  • Brain scans that measure beta amyloid load are not diagnostic for Alzheimer's.
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The Value of Exercise

  • Exercise has a real-time effect on blood sugar.
  • Insulin sensitivity is important for keeping blood sugar down.
  • Physical exercise changes gene expression and can lead to the expression of brain-derived neurotrophic factor (BDNF).
  • BDNF is a trophic hormone that is important for brain health.
  • Aerobic exercise is the most effective way to increase BDNF expression.
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Lifestyle Choices and Dementia

  • Dementia affects 5.4 million Americans and 40 million people globally.
  • Lifestyle choices can be leveraged to reduce the risk of dementia.
  • 50% of people age 85 or older will be affected by dementia.
  • Exercise is a powerful way to reduce the risk of dementia.
  • 20 minutes of aerobic exercise, 5 days a week, can significantly reduce the risk of dementia.
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The Problem with Alzheimer's Drugs

  • Alzheimer's drugs that target beta amyloid have not been effective.
  • Patients declined much more quickly when beta amyloid was targeted.
  • Brain scans that measure beta amyloid load are not diagnostic for Alzheimer's.
  • Pfizer has stopped pursuing the notion of an Alzheimer's drug that targets beta amyloid.
  • Plaque is the response to the problem, not the cause of the problem.
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The Importance of BDNF for Brain Health

  • Baseline BDNF levels are correlated with future risk for dementia.
  • BDNF increases the growth of new brain cells in the memory center and increases the connection of brain cells.
  • Lifestyle choices that are highly stressful, deprived of restorative sleep, higher in sugar, and overall stressful increase cortisol, which inhibits the growth of new brain cells.
  • Compromised brain cell population in areas like the memory center can be reversed by repopulating it with new brain cells.
  • A study done at UCLA in collaboration with researchers at the University of Pittsburgh demonstrated that stretching for a year resulted in lower levels of BDNF, declining memory function, and shrinkage on sophisticated brain scans in terms of hippocampus size.
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BDNF and Regrowth of Brain Cells

  • BDNF triggers hippocampal cell growth and also triggers the regrowth of brain cells in the subventricular layer of the ependyma.
  • Synaptoplasticity and neuroplasticity, the connection of brain cells, happens throughout the brain.
  • Synaptic pruning is the process of cutting back on the number of connections in order to refine the computer to make it work at its optimal level.
  • Neurons that fire together will wire together and those that don't will atrophy.
  • Exercising increases BDNF levels, which washes the brain in some way and signals to them to be more active and more likely to connect.
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The Evolutionary Advantage of Exercising for Brain Health

  • Exercising people should have higher levels of BDNF and ultimately be more able to survive and cognitively superior in evolutionary terms.
  • Healthy individuals who were able to hunt and gather and lead expeditions in our paleolithic times had higher levels of BDNF.
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Personalized Medicine and Tracking Data Points

  • Personalized medicine involves tracking data points such as genome and microbiome to improve overall health and reverse damage caused by lifestyle choices.
  • Tracking data points can help identify potential health risks and allow for early intervention.
  • Personalized medicine can help optimize brain health by identifying individual factors that affect BDNF levels and brain function.
  • Tracking data points can also help identify the most effective interventions for improving brain health.
  • Personalized medicine can help shift the focus from treating disease to optimizing health and preventing disease.
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Importance of Personalized Medicine

  • Tracking data points such as genome and microbiome can improve overall health and reverse damage caused by lifestyle choices.
  • Understanding movement and memory can help in making decisions about exercise routines.
  • Normal range is not optimal, and striving for optimal health is important.
  • Factors such as microbiome and diet can affect blood sugar levels and hemoglobin A1c.
  • Personalized medicine takes into account individual differences and can lead to better health outcomes.
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Exercise and Brain Health

  • Movement and exercise can improve memory and cognitive function.
  • Cardiovascular exercise is important for brain health, in addition to strength training.
  • BDNF is a protein that is important for brain health and is increased with exercise.
  • Personal risk factors for Alzheimer's disease can be reduced with exercise and a healthy lifestyle.
  • Understanding the science behind exercise can motivate individuals to make positive changes.
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Optimal Health and Blood Sugar Levels

  • Normal range is not optimal, and striving for optimal health is important.
  • Hemoglobin A1c levels should be between 5 and 5.4 for optimal health.
  • Fruit sugar, or fructose, can affect blood sugar levels and hemoglobin A1c.
  • Dietary factors such as fiber and microbiome can affect blood sugar levels.
  • Personalized medicine takes into account individual differences and can lead to better health outcomes.
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Factors Affecting Microbiome and Health

  • C-sections can lead to a disrupted microbiome and increase the potential for developing autism.
  • Factors such as diet and microbiome can affect blood sugar levels and overall health.
  • Vegan diets can be healthy, but may require supplementation for certain nutrients such as vitamin D, B12, and fat.
  • Personalized medicine takes into account individual differences and can lead to better health outcomes.
  • Understanding the factors that affect microbiome can lead to better health outcomes.
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