The SHOCKING SCIENCE On How To Prevent Diabetes & LOSE WEIGHT | Dr. Ben Bikman

Last updated: Jun 1, 2023

The video discusses how insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes, and how a shift in paradigm towards insulin resistance can lead to better treatment and prevention of these conditions.

The video features an interview with Dr. Ben Bikman, who discusses his book "Why We Get Sick" and the science behind preventing diabetes and losing weight. He explains that metabolic syndrome, which is often associated with high glucose levels, is actually a disease of profound insulin resistance. Bikman argues that a shift in paradigm from glucose to insulin is necessary to detect and treat the problem sooner and more effectively. He also suggests that a diet low in glucose can help lower blood glucose levels without upregulating insulin.

  • Insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes.
  • Changes in glucose levels should be viewed through the lens of insulin.
  • Type 2 diabetes is a disease of profound insulin resistance.
  • Shifting the paradigm away from glucose to insulin can lead to earlier detection and better treatment of the problem.
  • A low-carb, high-fat diet can help improve insulin sensitivity and reduce insulin resistance.
  • Insulin resistance is the underlying problem that leads to metabolic syndrome and type 2 diabetes.
  • Insulin resistance is also linked to other chronic diseases such as cancer and Alzheimer's.
  • Eating less glucose is the logical conclusion, but it requires a shift in paradigm.
  • A low-carbohydrate diet can improve insulin sensitivity and reduce insulin resistance.

The SHOCKING SCIENCE On How To Prevent Diabetes & LOSE WEIGHT | Dr. Ben Bikman - YouTube

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The Role of Insulin in Metabolic Syndrome

  • Insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes.
  • Changes in glucose levels should be viewed through the lens of insulin.
  • Type 2 diabetes is a disease of profound insulin resistance.
  • Insulin levels can go up by potentially multiples before glucose levels start to change.
  • Shifting the paradigm away from glucose to insulin can lead to earlier detection and better treatment of the problem.
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The Problem with the Glucocentric Paradigm

  • The prevailing glucocentric paradigm is that in type 2 diabetes, we have high glucose and we just need to do whatever we can to lower the glucose.
  • Pushing insulin up even higher than it was before works in lowering the glucose but reveals the problem in that it makes individuals fatter and sicker.
  • The more aggressively we push up insulin to lower the glucose, the more we are literally killing these individuals.
  • The paradigm should be that this is a high insulin state which is insulin resistance, and we need to lower that, not push down the glucose while pushing up the insulin.
  • Lowering sugar without increasing insulin can abate the problem.
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The Pathogenic Effects of Insulin Resistance

  • When type 2 diabetics are dying from heart disease, kidney failure, and other diseases, and having substantially increased risk of Alzheimer's, it's not the glucose that's doing that, it's the insulin resistance.
  • All the prototypical problems other than maybe blindness that we associate with diabetes are really insulin problems.
  • Hyperglycemia is pathogenic, but it's not the only issue.
  • Insulin resistance is the underlying problem that leads to metabolic syndrome and type 2 diabetes.
  • Insulin resistance is also linked to other chronic diseases such as cancer and Alzheimer's.
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The SHOCKING SCIENCE On How To Prevent Diabetes & LOSE WEIGHT | Dr. Ben Bikman - YouTube

The Role of Diet in Preventing and Treating Metabolic Syndrome

  • Diet is a powerful tool in preventing and treating metabolic syndrome.
  • A low-carb, high-fat diet can help improve insulin sensitivity and reduce insulin resistance.
  • A vegan diet is incompatible with human survival because it lacks essential nutrients that are only found in animal products.
  • A diet that includes animal products can provide essential nutrients that are necessary for optimal health.
  • Intermittent fasting can also help improve insulin sensitivity and reduce insulin resistance.
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Why is elevated glucose a problem?

  • Gluco hyperglycemia is acutely lethal and chronically lethal or long-term lethal.
  • Hyperglycemia can cause a non-ketotic coma where glucose levels get too high.
  • At around 200 milligrams per deciliter, glucose levels are too high for the kidneys to reabsorb.
  • The kidneys demand a certain amount of water to maintain a concentration that would keep it somewhat comparable with the rest of the body.
  • The person starts urinating out profound amounts of water, and the volume of blood starts to go down.
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What happens at a cellular level during a coma?

  • When urinating out too much water, all of that water is coming from the blood.
  • The volume of blood starts to go down, and pressure goes down.
  • The one tissue that is most susceptible to reductions in blood pressure is the brain.
  • If we don't have enough pressure in the cardiovascular system, we literally cannot get blood up to the brain.
  • The person will go unconscious and stay inside.
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Can keeping blood pressure elevated help tolerate more blood sugar?

  • Keeping blood pressure elevated could help tolerate more blood sugar.
  • However, it would lead to long-term consequences, which is the damage to nerves and capillaries.
  • Hyperglycemia or chronically elevated glucose is going to damage cells in capillaries and nerves in particular.
  • Advanced glycation end products are literally just molecules of taking glucose and binding it to amino acids that are just circulating in the blood.
  • Chronically elevated advanced glycation end products activate inflammation and apoptosis.
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What is the key factor in metabolic syndrome and type 2 diabetes?

  • Insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes.
  • Insulin resistance is the primary driver of metabolic syndrome and type 2 diabetes.
  • Insulin resistance is a state in which the body's cells become resistant to the effects of insulin.
  • Insulin resistance leads to hyperinsulinemia, which is chronically elevated insulin levels.
  • Chronically elevated insulin levels lead to metabolic dysfunction and chronic disease.
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Insulin Resistance and Metabolic Syndrome

  • Insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes.
  • When glucose levels are high, cells of the body have open doors for glucose.
  • Cells can't store glucose like the liver can, and so glucose sits around and gets converted into sorbitol.
  • Sorbitol is membrane impermeable and accumulates in cells, causing them to burst.
  • Drugs have been developed to block glucose from digesting or force the kidneys to excrete more glucose, but they have side effects.
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The Logical Conclusion: Eat Less Glucose

  • Many in the diabetes space cannot get themselves to the logical conclusion of eating less glucose.
  • Doctors' frame of reference is already drugs, and they see that the vast majority of people won't make dietary changes.
  • Food relational issues and addiction can make it difficult for people to make dietary changes.
  • Doctors' job is to treat patients, not necessarily to research all the science behind insulin resistance and metabolic syndrome.
  • Eating less glucose is the logical conclusion, but it requires a shift in paradigm.
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The Importance of Understanding Insulin Resistance

  • Insulin resistance is a key factor in metabolic syndrome and type 2 diabetes.
  • Insulin resistance is caused by too much insulin, not too little.
  • Insulin resistance is caused by a high-carbohydrate diet and a sedentary lifestyle.
  • Insulin resistance can be prevented and reversed by reducing carbohydrate intake and increasing physical activity.
  • Insulin resistance is a major risk factor for many chronic diseases, including heart disease, cancer, and Alzheimer's disease.
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The Benefits of a Low-Carbohydrate Diet

  • A low-carbohydrate diet can improve insulin sensitivity and reduce insulin resistance.
  • A low-carbohydrate diet can lead to weight loss and improved metabolic health.
  • A low-carbohydrate diet can reduce inflammation and improve cardiovascular health.
  • A low-carbohydrate diet can improve cognitive function and reduce the risk of Alzheimer's disease.
  • A low-carbohydrate diet can be sustainable and enjoyable with the right approach.
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The Importance of Diet

  • Eating fewer carbohydrates is a simple idea, but difficult to put into practice.
  • Asking someone to change their habits is asking them to do the most difficult thing they can do.
  • Many chronic health problems can be tied to diet.
  • Experimenting with diet can help alleviate chronic pain.
  • Changing diet can be empowering and address the true origins of the problem.
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The Prevalence of Insulin Resistance

  • Insulin resistance is likely the single most common health disorder in the world.
  • 88% of adults in the US have some aspect of the metabolic syndrome, which is really the insulin resistance syndrome.
  • Insulin resistance means forcing your system to pump too much insulin.
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The Definition of Insulin Resistance

  • Insulin resistance is defined at the level of the cell.
  • There are two phenomena that must occur for it to be insulin resistance: insulin resistance itself and hyperinsulinemia.
  • Insulin resistance means the cell is not responding to insulin as it should.
  • Hyperinsulinemia means there is too much insulin in the blood.
  • Insulin resistance and hyperinsulinemia are both necessary for the development of metabolic syndrome and type 2 diabetes.
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The Importance of Insulin Resistance

  • Insulin, not glucose, is the key factor in metabolic syndrome and type 2 diabetes.
  • Insulin resistance is the root cause of metabolic syndrome and type 2 diabetes.
  • Insulin resistance is also linked to other chronic health problems, such as cardiovascular disease and cancer.
  • Insulin resistance can be prevented and reversed through lifestyle changes, such as diet and exercise.
  • A shift in paradigm towards insulin resistance can lead to better treatment and prevention of these conditions.
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Insulin Resistance and Hyperinsulinemia

  • Insulin is responsible for allowing glucose to enter cells.
  • Insulin resistance occurs when some cells of the body do not respond to insulin as well as they used to.
  • Hyperinsulinemia is the chronically elevated insulin levels that often accompany insulin resistance.
  • Insulin resistance and hyperinsulinemia are the two sides of the same coin.
  • Insulin has a hand in thousands of biochemical reactions throughout the body.
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Physiological and Pathological Insulin Resistance

  • Physiological insulin resistance occurs during puberty and pregnancy.
  • The body deliberately pushes up its insulin and changes the efficacy of the insulin throughout the body in order to facilitate substantial growth.
  • Pregnancy-related insulin resistance helps the baby grow and get fat, which is necessary for healthy brain development.
  • Pathological insulin resistance is associated with conditions like high blood pressure and erectile dysfunction.
  • Physiological insulin resistance serves a useful or physiological purpose, while pathological insulin resistance is a pathological condition.
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Cells That Do Not Get Insulin Resistant

  • Muscle cells can become very insulin resistant, which is a problem because they are not pulling in glucose as well.
  • The liver can become insulin resistant in some aspects, while some of its processes stay insulin sensitive.
  • Gluteal femoral fat cells will virtually forever maintain perfect insulin sensitivity.
  • Visceral fat cells, which are fat cells that are within the abdominal space and behind our muscles, can become insulin resistant.
  • Not all fat cells are the same, and some fat cells can become insulin resistant while others maintain perfect insulin sensitivity.
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The Importance of Fat for Brain Development

  • Babies must have enough fat to make enough ketones to feed the brain.
  • If a baby is too skinny, it is very likely the baby will suffer from learning disabilities as the baby grows.
  • Humans are the only land-based mammals that are born obese and with a brain and head that is bigger than the birth canal.
  • The massive metabolic demands in our brain require that babies have enough fat to make enough ketones to fuel brain growth during the newborn years.
  • If a baby is born prematurely or too skinny, it is important to fatten the baby up as quickly as possible to ensure healthy brain development.
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